Apr 10, 2014 · Pol β has been an excellent model enzyme for studying the nucleotidyl transferase reaction and substrate discrimination at a molecular level. In ...
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Jul 29, 2009 · Unpaired nucleotides are trimmed by an exonuclease such as the Artemis:DNA PKcs complex [45]. The gaps are ultimately filled by template- ...
Jul 23, 2009 · The X Family of DNA polymerases in eukaryotic cells consists of Terminal Transferase, and DNA polymerases β, λ, and μ.
DNA polymerase beta is the smallest among the eukaryotic DNA polymerases. It is typically described as a DNA repair enzyme, involved in various types of DNA ...
Dec 31, 2019 · Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β. Mallory R. Smith. Mallory R ...
Feb 26, 2016 · Genetic studies in yeast have shown that RNaseH2 mutants suffer replication stress and require translesion synthesis (TLS) to avoid accumulation ...
DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone ...
Jan 22, 2020 · DNA polymerase (pol) μ primarily inserts ribonucleotides into a single-nucleotide gapped DNA intermediate, and the ligation step plays a ...
Jun 2, 2010 · Although DNA polymerases discriminate against ribonucleotides, many therapeutic nucleotide analogs that target polymerases have sugar ...
Mar 31, 2021 · The Pol X family consists of four members: Pol λ, μ, and β and terminal transferase or TdT. Members of the family X are involved in base ...